The impact of human activities and lifestyles on the interlinked microbiota and health of humans and of ecosystems

摘要: Abstract Plants, animals and humans, are colonized by microorganisms (microbiota) transiently exposed to countless others. The microbiota affects the development function of essentially all organ systems, contributes adaptation evolution, while protecting against pathogenic toxins. Genetics lifestyle factors, including diet, antibiotics other drugs, exposure natural environment, affect composition microbiota, which influences host health through modulation interrelated physiological systems. These include immune system regulation, metabolic endocrine pathways, brain epigenetic modification genome. Importantly, parental microbiotas have transgenerational impacts on progeny. Humans, plants share similar relationships with microbes. Research paradigms from humans mammals, amphibians, insects, planktonic crustaceans demonstrate influence environmental microbial ecosystems organisms, indicate links between internal diversity good health. Therefore, overlapping compositions, interconnected roles microbes in human, animal plant should be considered within broader context terrestrial aquatic that challenged human agricultural industrial activities. Here, we propose research priorities organizational, educational administrative measures will help identify safe microbe-associated health-promoting modalities practices. In spirit an expanding version “One health” includes its relation cultures habits (EcoHealth), urge lifestyle-microbiota-human nexus taken into account societal decision making.