Hemodialysis of acetaminophen in uremic patients.

摘要: The effect of the artificial kidney on removal acetaminophen was investigated in 6 chronic hemodialysis patients. Acetaminophen, 650 mg, given orally 2 hrs prior to hemodialysis. Plasma and dialysate samples were collected periodically over 3 hours analyzed by HPLC for content. Dialysis clearance calculated Arterial-venous difference simultaneous measurement. extraction efficiency hollow-fiber dialyzers averaged 47.5%. mean dialysis 112 ml/min measured with blood as body fluid reference confirmed calculation using A 70.5 mg 11% administered dose removed during hour period. beta phase had a half-life 1.6 our patients compared 2.0 reported both normal uremic Despite favorable ratio dialyzer clearance, is not very effective competing liver parent compound because drug's short rapid hepatic metabolism. Hence, patient may need dosage adjustment or following