THE INTERSTITIAL FLUID OF SOLID TUMORS.

摘要: Summary The interstitial fluid of a solid tumor, consisting the liquid phase interposed between newly formed vascular walls tumor and plasma membrane neoplastic cells, has been sampled from chamber enclosed into mass. “tension” normal tissues was sufficient to produce continuous outflow sampling device. In some tumors, but not in all them, pressure needed stop this twice as large that required for subcutaneous tissue, it similar measured skin after venous obstruction. technic described detail. Each sample compared with blood serum flowing out mass, obtained by same peritoneal fluid, lymph thoracic duct tumor-bearing rats. fluids were first tested sterility then analyzed total protein, nonprotein N, urea, free amino acids, glucose, lactic acid, sterols, lipid phosphorus, chloride, sodium, potassium. main purpose better characterization milieu which cells live. results refer small tumors (5–10 gm.) Walker carcinoma 256, Fibrosarcoma 4956, Hepatoma 5123, 7974, Novikoff hepatoma. characterized very low content glucose high levels acid. Data are reported on passage they suggest occurs means transfer mechanism simple diffusion. A “fermentative type” peculiar produced also without any sign neoplasia being present. concentration proteins about 33 per cent lower than tumors. This reduction constant each persisted during growth, disappeared only when device surrounded necrotic tissue. α-globulins reduced, albumin-globulin ratio equal serum. acid level generally higher entering or leaving behavior uniform, no conclusion could be drawn. cholesterol phosphorus one-fourth serum; however, values similar. gross composition maintained lymph, despite presence foci known changes metabolism cell population.