Insulin and glucose profiles during continuous subcutaneous insulin infusion compared with injection of a long-acting insulin in Type 2 diabetes.

摘要: Aims  To compare insulin and glucose profiles during basal continuous subcutaneous infusion of a rapid-acting analogue once daily injection long-acting in Type 2 diabetes. Methods  Twenty-one patients with diabetes treated oral glucose-lowering agents were randomized this two-period crossover study to an equivalent 24-h dose aspart subsequently once-daily bedtime glargine, or vice versa, for eight consecutive days. Plasma recorded. Results  On the last day each treatment period, area under curve (AUC) was 10% lower on regimen compared (P = 0.002). This accomplished by flat exogenous profile peaking injected (AUC 74% higher after pre-injection levels (P = 0.001)). During 6 days intra-subject variability fasting mornings 41% (P = 0.012). The corresponding only showed tendency be as (28%; P = 0.104). Thirteen symptomatic-only minor hypoglycaemic episodes recorded entire period three period. Conclusions  Basal improved plasma (more variability) (lower AUC) diabetes.