Absorption of isophane (NPH) insulin and its clinical implications.
作者： T Lauritzen , S Pramming , E A Gale , T Deckert , C Binder
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摘要: Absorption of 125I-NPH insulin (125I-isophane insulin) (40 IU/ml) was studied in eight diabetics given 50% and 150% their normal daily dose insulin. Insulin absorption correlated with plasma (r = 0.97, p less than 0.001) blood glucose -0.87, 0.01) concentrations. slower at higher doses, so that trebling the only doubled amount absorbed over first 24 hours. The elimination half time (t12) about five minutes. Thus, disappearance radiolabelled is a reliable quantitative index absorption; subcutaneous degradation, if present, minimal constant. Changes dise intermediate-acting further increases large variation absorption. This implies minor adjustments intermediate dosage are probably futile.
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