Vemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 Mutations

作者: David M. Hyman , Igor Puzanov , Vivek Subbiah , Jason E. Faris , Ian Chau

DOI: 10.1056/NEJMOA1502309

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摘要: Background BRAF V600 mutations occur in various nonmelanoma cancers. We undertook a histology-independent phase 2 “basket” study of vemurafenib in BRAF V600 mutation–…

参考文章(31)
Frank V. Fossella, Russell DeVore, Ronald N. Kerr, Jeffrey Crawford, Ronald R. Natale, Frank Dunphy, Leonard Kalman, Vincent Miller, Jin Soo Lee, Melvin Moore, David Gandara, Daniel Karp, Everett Vokes, Mark Kris, Yong Kim, Francis Gamza, Luz Hammershaimb, , Randomized Phase III Trial of Docetaxel Versus Vinorelbine or Ifosfamide in Patients With Advanced Non–Small-Cell Lung Cancer Previously Treated With Platinum-Containing Chemotherapy Regimens Journal of Clinical Oncology. ,vol. 18, pp. 2354- 2362 ,(2000) , 10.1200/JCO.2000.18.12.2354
S. Kopetz, J. Desai, E. Chan, J. R. Hecht, P. J. O'Dwyer, R. J. Lee, K. B. Nolop, L. Saltz, PLX4032 in metastatic colorectal cancer patients with mutant BRAF tumors. Journal of Clinical Oncology. ,vol. 28, pp. 3534- 3534 ,(2010) , 10.1200/JCO.2010.28.15_SUPPL.3534
Edna T Kimura, Marina N Nikiforova, Zhaowen Zhu, Jeffrey A Knauf, Yuri E Nikiforov, James A Fagin, None, High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Research. ,vol. 63, pp. 1454- 1457 ,(2003)
John A. Curtin, Jane Fridlyand, Toshiro Kageshita, Hetal N. Patel, Klaus J. Busam, Heinz Kutzner, Kwang-Hyun Cho, Setsuya Aiba, Eva-Bettina Bröcker, Philip E. LeBoit, Dan Pinkel, Boris C. Bastian, Distinct Sets of Genetic Alterations in Melanoma The New England Journal of Medicine. ,vol. 353, pp. 2135- 2147 ,(2005) , 10.1056/NEJMOA050092
Julien Haroche, Fleur Cohen-Aubart, Jean-François Emile, Laurent Arnaud, Philippe Maksud, Frédéric Charlotte, Philippe Cluzel, Aurélie Drier, Baptiste Hervier, Neïla Benameur, Sophie Besnard, Jean Donadieu, Zahir Amoura, Dramatic efficacy of vemurafenib in both multisystemic and refractory Erdheim-Chester disease and Langerhans cell histiocytosis harboring the BRAF V600E mutation Blood. ,vol. 121, pp. 1495- 1500 ,(2013) , 10.1182/BLOOD-2012-07-446286
Anirudh Prahallad, Chong Sun, Sidong Huang, Federica Di Nicolantonio, Ramon Salazar, Davide Zecchin, Roderick L. Beijersbergen, Alberto Bardelli, René Bernards, Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR Nature. ,vol. 483, pp. 100- 103 ,(2012) , 10.1038/NATURE10868
Christopher D.M. Fletcher, Heikki Joensuu, George D. Demetri, Margaret von Mehren, Charles D. Blanke, Annick D. Van den Abbeele, Burton Eisenberg, Peter J. Roberts, Michael C. Heinrich, David A. Tuveson, Samuel Singer, Milos Janicek, Jonathan A. Fletcher, Stuart G. Silverman, Sandra L. Silberman, Renaud Capdeville, Beate Kiese, Bin Peng, Sasa Dimitrijevic, Brian J. Druker, Christopher Corless, Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. The New England Journal of Medicine. ,vol. 347, pp. 472- 480 ,(2002) , 10.1056/NEJMOA020461
E.A. Eisenhauer, P. Therasse, J. Bogaerts, L.H. Schwartz, D. Sargent, R. Ford, J. Dancey, S. Arbuck, S. Gwyther, M. Mooney, L. Rubinstein, L. Shankar, L. Dodd, R. Kaplan, D. Lacombe, J. Verweij, New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1) European Journal of Cancer. ,vol. 45, pp. 228- 247 ,(2009) , 10.1016/J.EJCA.2008.10.026
Julien Haroche, Frédéric Charlotte, Laurent Arnaud, Andreas von Deimling, Zofia Hélias-Rodzewicz, Baptiste Hervier, Fleur Cohen-Aubart, David Launay, Annette Lesot, Karima Mokhtari, Danielle Canioni, Louise Galmiche, Christian Rose, Marc Schmalzing, Sandra Croockewit, Marianne Kambouchner, Marie-Christine Copin, Sylvie Fraitag, Felix Sahm, Nicole Brousse, Zahir Amoura, Jean Donadieu, Jean-François Emile, High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses Blood. ,vol. 120, pp. 2700- 2703 ,(2012) , 10.1182/BLOOD-2012-05-430140
J S Miguel, J Bladé, B Barlogie, K Anderson, M Gertz, M Dimopoulos, J Westin, P Sonneveld, H Ludwig, G Gahrton, M Beksac, J Crowley, A Belch, M Boccadaro, I Turesson, D Joshua, D Vesole, R Kyle, R Alexanian, G Tricot, M Attal, G Merlini, R Powles, P Richardson, K Shimizu, P Tosi, G Morgan, S V Rajkumar, B G M Durie, , J-L Harousseau, International uniform response criteria for multiple myeloma Leukemia. ,vol. 20, pp. 1467- 1473 ,(2006) , 10.1038/SJ.LEU.2404284