Redox and pH Responsive Poly (Amidoamine) Dendrimer-Heparin Conjugates via Disulfide Linkages for Letrozole Delivery.
作者： Thanh Luan Nguyen , Thi Hiep Nguyen , Cuu Khoa Nguyen , Dai Hai Nguyen , None
DOI: 10.1155/2017/8589212
关键词:
摘要: Heparin (Hep) conjugated to poly (amidoamine) dendrimer G3.5 (P) via redox-sensitive disulfide bond (P-SS-Hep) was studied. The redox and pH dual-responsive nanocarriers were prepared by a simple method that minimized many complex steps as previous studies. functional characterization of coated Hep investigated the proton nuclear magnetic resonance spectroscopy. size formation characterized dynamic light scattering, zeta potential, transmission electron microscopy. P-SS-Hep spherical in shape with average diameter about 11 nm loaded more than 20% letrozole. This drug carrier could not only eliminate toxicity cells improve drugs solubility but also increase biocompatibility system under reductive environment glutathione. In particular, enhance effectiveness cancer therapy after removing from surface. These results demonstrated conjugates be promising candidate responsive for chemotherapy.
hindawi.com
core.ac.uk参考文章(29)
Dai Hai Nguyen, Jung Seok Lee, Jong Hoon Choi, Yunki Lee, Joo Young Son, Jin Woo Bae, Kihwang Lee, Ki Dong Park, Heparin nanogel-containing liposomes for intracellular RNase delivery Macromolecular Research. ,vol. 23, pp. 765- 769 ,(2015) , 10.1007/S13233-015-3093-2
Dai Hai Nguyen, Jung Seok Lee, Jin Woo Bae, Jong Hoon Choi, Yunki Lee, Joo Young Son, Ki Dong Park, Targeted doxorubicin nanotherapy strongly suppressing growth of multidrug resistant tumor in mice International Journal of Pharmaceutics. ,vol. 495, pp. 329- 335 ,(2015) , 10.1016/J.IJPHARM.2015.08.083
Yan Li, Hai He, Xinru Jia, Wan-Liang Lu, Jinning Lou, Yen Wei, A dual-targeting nanocarrier based on poly(amidoamine) dendrimers conjugated with transferrin and tamoxifen for treating brain gliomas Biomaterials. ,vol. 33, pp. 3899- 3908 ,(2012) , 10.1016/J.BIOMATERIALS.2012.02.004
Yoshinori Kakizawa, Atsushi Harada, Kazunori Kataoka, Glutathione-Sensitive Stabilization of Block Copolymer Micelles Composed of Antisense DNA and Thiolated Poly(ethylene glycol)-block-poly(l-lysine): A Potential Carrier for Systemic Delivery of Antisense DNA Biomacromolecules. ,vol. 2, pp. 491- 497 ,(2001) , 10.1021/BM000142L
Heebeom Koo, Geun-woo Jin, Hyunseo Kang, Yan Lee, Hye Yeong Nam, Hyung-suk Jang, Jong-Sang Park, A new biodegradable crosslinked polyethylene oxide sulfide (PEOS) hydrogel for controlled drug release. International Journal of Pharmaceutics. ,vol. 374, pp. 58- 65 ,(2009) , 10.1016/J.IJPHARM.2009.03.010
Rong Qi, Yu Gao, Yin Tang, Rui-Rui He, Tao-Le Liu, Yun He, Sheng Sun, Bo-Yu Li, Yang-Bing Li, George Liu, PEG-conjugated PAMAM Dendrimers Mediate Efficient Intramuscular Gene Expression Aaps Journal. ,vol. 11, pp. 395- 405 ,(2009) , 10.1208/S12248-009-9116-1
Shin J. Kang, Subconjunctival Nanoparticle Carboplatin in the Treatment of Murine Retinoblastoma Archives of Ophthalmology. ,vol. 127, pp. 1043- 1047 ,(2009) , 10.1001/ARCHOPHTHALMOL.2009.185
Durairaj Chandrasekar, Ramakrishna Sistla, Farhan J Ahmad, Roop K Khar, Prakash V Diwan, None, The development of folate-PAMAM dendrimer conjugates for targeted delivery of anti-arthritic drugs and their pharmacokinetics and biodistribution in arthritic rats. Biomaterials. ,vol. 28, pp. 504- 512 ,(2007) , 10.1016/J.BIOMATERIALS.2006.07.046
D A Tomalia, H Baker, J Dewald, M Hall, G Kallos, S Martin, J Roeck, J Ryder, P Smith, A New Class of Polymers: Starburst-Dendritic Macromolecules Polymer Journal. ,vol. 17, pp. 117- 132 ,(1985) , 10.1295/POLYMJ.17.117
Dai Hai Nguyen, Yoon Ki Joung, Jong Hoon Choi, Hyun Tae Moon, Ki Dong Park, Targeting ligand-functionalized and redox-sensitive heparin-Pluronic nanogels for intracellular protein delivery. Biomedical Materials. ,vol. 6, pp. 055004- ,(2011) , 10.1088/1748-6041/6/5/055004