Does flushing the endometrial cavity with follicular fluid after oocyte retrieval affect pregnancy rates in subfertile women undergoing intracytoplasmic sperm injection? A randomized controlled trial.

摘要: Objective: Follicular fluid of mature oocytes is rich in growth factors and cytokines that may exert paracrine autocrine effects on implantation. The aim this study was to investigate if flushing the endometrial cavity with follicular after oocyte retrieval improved pregnancy rates subfertile women undergoing intracytoplasmic sperm injection (ICSI). Study design: One hundred ICSI between April 2012 September at centre for reproductive medicine, Cairo University, Egypt were enrolled open label, parallel randomized controlled study. Patients into two groups start treatment using a computer-generated programme sealed opaque envelopes: group (n = 50) control 50). Inclusion criteria were: age 20–38 years; basal follicle-stimulating hormone 1000 pg/ml <4000 day human chorionic gonadotrophin administration. Exclusion evidence endometriosis; uterine myoma; hydrosalpinges; endocrinological disorders; history implantation failure previous in-vitro fertilization/ICSI cycles; severe male factor infertility. Results: Clinical higher compared [354% (17/48) vs 319% (15/47); p 0718] (18.6% 11.3%; 0.153), respectively. However, difference not statistically significant. Conclusion: Flushing neither nor adversely affected clinical ICSI.