Blood clearance of 99mTc-phytate for evaluation of hepatic dysfunction in rats.
作者： Hiroshi SHIBATA , Hiroshi HARA
DOI: 10.2131/JTS.13.83
关键词:
摘要: Organ distribution pattern, hepatic uptake ratio, and blood clearance were examined by giving 99mTc-phytate (99mTc-P) to the normal rats. At same time, relation between severity of function or ratio 99mTc-P was studied using rats with acute dysfunction experimentally induced carbon tetrachloride (CCl4) administration. Furthermore, a comparative discussion on test made serum transaminase histological liver. It appeared appropriate administer at dose 500 micrograms/kg in order obtain an effective curve. A major part intravenously administered take up into liver, while remainder small amount spleen, kidneys, lung, so on. Little recognized thyroid gland. The reached maximum 15 minutes after disappearance rate from decreased increase CCl4 passage time showed sensitive reaction for equally higher than
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