Platycodin D Induces Apoptosis in MCF-7 Human Breast Cancer Cells
作者： Ji Sun Yu , An Keun Kim
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摘要: Abstract Platycodin D (PD), a major constituent isolated from the root of Platycodon grandiflorum, has been suggested to possess anticancer activities, as indicated by its capabilities induce mitotic arrest and apoptosis in several cancer cells. However, little is known underlying action mechanism. This study first investigate effect PD human breast cell, MCF-7. Our data showed that exhibited marked cell growth inhibition inducing apoptosis. induction was associated with activation caspase-8 -9 activities poly(ADP-ribose) polymerase. triggered mitochondrial apoptotic pathway, up-regulation levels cellular Bax down-regulation Bcl-2 caspase-9 activation. We found induced proteolytic Bid, member proapoptotic family, implicating PD-induced possibly being functionally linked death receptor-mediated pathway. The treatment also a...
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Michael O. Hengartner, The biochemistry of apoptosis Nature. ,vol. 407, pp. 770- 776 ,(2000) , 10.1038/35037710
James M. Olson, Andrew R. Hallahan, p38 MAP kinase: a convergence point in cancer therapy Trends in Molecular Medicine. ,vol. 10, pp. 125- 129 ,(2004) , 10.1016/J.MOLMED.2004.01.007
Po-Lin Kuo, Chung-Yi Chen, Ya-Ling Hsu, Isoobtusilactone A Induces Cell Cycle Arrest and Apoptosis through Reactive Oxygen Species/Apoptosis Signal-Regulating Kinase 1 Signaling Pathway in Human Breast Cancer Cells Cancer Research. ,vol. 67, pp. 7406- 7420 ,(2007) , 10.1158/0008-5472.CAN-07-1089
Gabriel Nuñez, Mary A Benedict, Yuanmimg Hu, Naohiro Inohara, Caspases: the proteases of the apoptotic pathway Oncogene. ,vol. 17, pp. 3237- 3245 ,(1998) , 10.1038/SJ.ONC.1202581
Mun-Ock Kim, Dong-Oh Moon, Yung Hyun Choi, Jae-Dong Lee, Nam Deuk Kim, Gi-Young Kim, Platycodin D induces mitotic arrest in vitro, leading to endoreduplication, inhibition of proliferation and apoptosis in leukemia cells. International Journal of Cancer. ,vol. 122, pp. 2674- 2681 ,(2008) , 10.1002/IJC.23442
Teiji Wada, Josef M Penninger, Mitogen-activated protein kinases in apoptosis regulation. Oncogene. ,vol. 23, pp. 2838- 2849 ,(2004) , 10.1038/SJ.ONC.1207556
Marion MacFarlane, Ann C Williams, Apoptosis and disease: a life or death decision EMBO reports. ,vol. 5, pp. 674- 678 ,(2004) , 10.1038/SJ.EMBOR.7400191
Mun-Ock Kim, Dong-Oh Moon, Yung Hyun Choi, Dong Yeok Shin, Ho Sung Kang, Byung Tae Choi, Jae-Dong Lee, Wei Li, Gi-Young Kim, Platycodin D induces apoptosis and decreases telomerase activity in human leukemia cells. Cancer Letters. ,vol. 261, pp. 98- 107 ,(2008) , 10.1016/J.CANLET.2007.11.010
Hye Jeong Wie, Hai Lin Zhao, Jeong Hwa Chang, Yeong Shik Kim, In Kyeong Hwang, Geun Eog Ji, Enzymatic modification of saponins from Platycodon grandiflorum with Aspergillus niger. Journal of Agricultural and Food Chemistry. ,vol. 55, pp. 8908- 8913 ,(2007) , 10.1021/JF0716937
Roya Khosravi-Far, Death receptor signals to mitochondria. Cancer Biology & Therapy. ,vol. 3, pp. 1051- 1057 ,(2004) , 10.4161/CBT.3.11.1173