Apoptotic Signaling Pathways in Glioblastoma and Therapeutic Implications.
作者： Silvia Anahi Valdés-Rives , Diana Casique-Aguirre , Liliana Germán-Castelán , Marco A. Velasco-Velázquez , Aliesha González-Arenas
DOI: 10.1155/2017/7403747
关键词:
摘要: Glioblastoma multiforme (GBM) is the most hostile type of brain cancer. Its aggressiveness due to increased invasion, migration, proliferation, angiogenesis, and a decreased apoptosis. In this review, we discuss role key regulators apoptosis in GBM glioblastoma stem cells. Given their importance etiology pathogenesis GBM, these signaling molecules may represent potential therapeutic targets.
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