Evidence suggests rigid aortic grafts increase systolic blood pressure: Results of a preliminary study

作者: T. O′Brien , L. Morris , T. McGloughlin

DOI: 10.1016/J.MEDENGPHY.2007.01.004

关键词:

摘要: Abdominal aortic aneurysm (AAA) is a serious complication of the aorta and treated using vascular bypass grafts. Two main classes graft are available to treat AAA; grafts implanted by open surgery stent-grafts minimally invasive endovascular techniques. Both consist an section which bifurcates into two iliac sections. It has been hypothesized that implantation serve significantly increase abdominal pressures. In this study, open-loop computer-controlled pumping system was built produce physiologically realistic pressure flow-rates. Models compliant aneurysm, walled tapered were manufactured injection moulding technique fused deposition modelling used create rigid graft. A specific transient flow-rate waveform then applied at inlet each model resulting waveforms 30 mm upstream from bifurcation recorded. Peak measurements recorded over course pulse for model. The found have systolic 107 mmHg while complaint 153 mmHg. had peak 199 graft, dropped 142 data suggests implanting in place vitro flow circuit can pressures may alleviate problem.

参考文章(32)
D Liepsch, T Matsuo, B Lesniak, G Pflugbeil, Flow visualization and 1- and 3-D laser-Doppler-anemometer measurements in models of human carotid arteries Clinical Hemorheology and Microcirculation. ,vol. 18, pp. 1- 30 ,(1998)
Mark Langsfield, Endovascular grafting : advanced treatment for vascular disease Annals of Vascular Surgery. ,vol. 15, pp. 722- 722 ,(2001) , 10.1007/S10016-001-0093-9
D. W. Holdsworth, D. W. Rickey, M. Drangova, D. J. M. Miller, A. Fenster, Computer-controlled positive displacement pump for physiological flow simulation Medical & Biological Engineering & Computing. ,vol. 29, pp. 565- 570 ,(1991) , 10.1007/BF02446086
Håkan Åstrand, Åsa Rydén-Ahlgren, Tomas Sandgren, Toste Länne, Age-related increase in wall stress of the human abdominal aorta: an in vivo study. Journal of Vascular Surgery. ,vol. 42, pp. 926- 931 ,(2005) , 10.1016/J.JVS.2005.07.010
Z. D. Shi, S. H. Winoto, T. S. Lee, Experimental investigation of pulsatile flows in tubes. Journal of Biomechanical Engineering-transactions of The Asme. ,vol. 119, pp. 213- 216 ,(1997) , 10.1115/1.2796082
Michael F. O??Rourke, Alfredo L Pauca, Augmentation of the aortic and central arterial pressure waveform Blood Pressure Monitoring. ,vol. 9, pp. 179- 185 ,(2004) , 10.1097/00126097-200408000-00002
A. R. Koslow, R. R. Stromberg, L. I. Friedman, R. J. Lutz, S. L. Hilbert, P. Schuster, A Flow System for the Study of Shear Forces Upon Cultured Endothelial Cells Journal of Biomechanical Engineering-transactions of The Asme. ,vol. 108, pp. 338- 341 ,(1986) , 10.1115/1.3138625
P SEGERS, E RIETZSCHEL, S HEIREMAN, M DEBUYZERE, T GILLEBERT, P VERDONCK, L VANBORTEL, Carotid Tonometry Versus Synthesized Aorta Pressure Waves for the Estimation of Central Systolic Blood Pressure and Augmentation Index American Journal of Hypertension. ,vol. 18, pp. 1168- 1173 ,(2005) , 10.1016/J.AMJHYPER.2005.04.005