Nitric oxide production and NO synthase gene expression contribute to vascular regulation during exercise.

摘要: Nitric oxide (NO) is a vasodilator produced under normal physiologic conditions primarily by the vascular endothelium lining all blood vessels. The primary stimulus for production of nitric constitutive endothelial synthase (ECNOS, Type II) found in vessels most likely shear stress, frictional force, caused flowing through During exercise there an increase cardiac output and redistribution flow to skeletal muscle coronary circulation. These adjustments provide increased oxygen delivery support aerobic energy sustain response. NO may be involved regulation tone exercising promoting, enhancing metabolic vasodilation. In addition, capillary regulate consumption mitochondria chemical interactions between iron-sulfur center these enzymes. Finally, brief training alter gene expression enzyme, synthase, which forms part adaptation seen after training. Furthermore, if genetic predisposition produce NO, as world class athletes or animals bred race, contribute spectacular performance. three potential roles will discussed data presented each our review.