FARNA: knowledgebase of inferred functions of non-coding RNA transcripts.

摘要: Non-coding RNA (ncRNA) genes play a major role in control of heterogeneous cellular behavior. Yet, their functions are largely uncharacterized. Current available databases lack in-depth information ncRNA across spectrum various cells/tissues. Here, we present FARNA, knowledgebase inferred 10,289 human transcripts (2,734 microRNA and 7,555 long ncRNA) 119 tissues 177 primary cells human. Since transcription factors (TFs) TF co-factors (TcoFs) crucial components regulatory machinery for activation gene transcription, processes diseases which TFs TcoFs involved suggest the they regulate. In transcript from whose co-express with controlled by these considered cell/tissue. Transcripts were annotated using statistically enriched GO terms, pathways cells/tissues based on guilt-by-association principle. Expression profiles Cap Analysis Gene (CAGE) provided. having most comprehensive function annotation ncRNAs widest cells/tissues, has potential to greatly contribute our understanding roles mechanisms FARNA can be accessed at: http://cbrc.kaust.edu.sa/farna.