Estrogen and Castration-Induced Effects on Canine Prostatic Fine Structure and Ci9-steroid Metabolism

摘要: Canine prostate tissue taken from the same gland before and 30 days after administration of estradiol-17β cyclopentanepropionate (ECP) or orchiectomy was examined by light electron microscopy incubated with 14C-labeled testosterone, 4-androstene-3,17-dione (androstenedione) 17β-hydroxy-5α-androstan- 3-one (5α-dihydrotestosterone) without cofactor supplementation. Whereas gonadectomy caused atrophy prostatic epithelium, dose schedule ECP induced squamous metaplasia. These histological markers were characteristic end-points experimental procedures. Cellular changes less specific when studied microscopy. treatment castration gave rise to similar nuclear cytoplasmic alterations in glandular notably change euchromatin heterochromatin patterns. Only presence numerous lysosomes more severe effects on granular endoplasmic reticulum served distinguish fine structure castrates that E...