Hyperhomocysteinemia in hemodialysis patients: Effects of 12-month supplementation with hydrosoluble vitamins

摘要: Hyperhomocysteinemia in hemodialysis patients: Effects of 12-month supplementation with hydrosoluble vitamins. Background High-efficiency may induce a deficiency Supplementation B-complex vitamins has been shown to lower serum homocysteine concentrations several groups, but relatively few studies have concerned patients. Our objectives were determine the status large cohort unsupplemented patients and assess effects on over one year. Methods Serum total (tHcy), vitamin B 12 , folate, pyridoxal-5′-phosphate (P-5′-P; active moiety 6 ), as well red blood cell folate concentrations, measured 168 chronic dialysis three times weekly high-efficiency not supplemented Their methylenetetrahydrofolate reductase C677T (MTHFR) genotypes also determined (homozygotes TT, heterozygotes CT, without mutation CC). All involved then (once daily by mouth, DiaVite ® ; RD tHcy significantly decreased 23.5 ± 7.6 μmol/L after six months ( P appeared particularly significant TT at months. Conclusions 1 ) was present 100% our 2 Nearly 40% deficient . 3 resulted reductions for all genotypes. 4 The impact proposed protocol found maintained, did increase further same regimen. 5 addition intravenous folic acid associated more pronounced decrease