Precision Medicine for Hypertension Management in Chronic Kidney Disease: Relevance of SPRINT for Therapeutic Targets in Nondiabetic Renal Disease
作者： Marcel Ruzicka , Kevin D. Burns , Swapnil Hiremath
DOI: 10.1016/J.CJCA.2017.01.007
关键词:
摘要: Abstract In this review we evaluate the literature to determine if lower blood pressure (BP) targets are beneficial for patients with nondiabetic chronic kidney disease (CKD). M odification of D iet in R enal isease (MDRD), A frican merican S tudy K idney Disease and Hypertension (AASK), amipril E fficacy i n N ephropathy-2 (REIN-2), designed assess benefit BP on progression CKD, generally came same negative conclusion. They were not powered an effect cardiovascular outcomes. The ystolic Blood Pr essure tervention T rial (SPRINT) was first trial address issue, showed a clear targeted achieved BP. SPRINT did show any renal benefits from BP, it outcome, enrolled less "renal risk" per se. distinguishing feature compared other large trials is that highlighted importance precise measurement methods defining hypertension treatment. Accordingly, propose truly "game-changing" clinical sets bar management select CKD. these patients, systolic target depends critically method:
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