Optimizing the protocol for pulmonary cryoablation: a comparison of a dual- and triple-freeze protocol.

摘要: The purpose of this study was to compare a double freeze–thaw protocol triple for pulmonary cryoablation utilizing an in vivo porcine lung model. A total 18 cryoablations were performed normal percutaneous technique with 9 each double- (10-5-10) and triple-freeze (3-3-7-7-5) protocol. Serial noncontrast CT images obtained during the ablation. imaging findings pathology reviewed. No changes identified initial freeze cycle either However, first thaw cycle, region ground glass opacity developed around probe both protocols. Because shorter protocol, apparent sooner (6 vs. 13 min). Also, despite time (15 20 min), ablation zone not significantly different from (mean diameter: 1.67 ± 0.41 cm 1.66 0.21 cm, P = 0.77; area: 2.1 0.48 cm2 1.99 0.62 cm2, 0.7; circularity: 0.95 0.04 0.96 0.03, 0.62, respectively). This suggests that there may be several advantages cryoablation, including earlier identification associated ablation, promise procedure or larger zones theoretically, more effective cytotoxicity related additional cycle.