Characterisation of the ventilatory response to hypoxia in a model of transgenic anemic mice

摘要: Abstract Both polycythemia and the increase in hypoxic ventilatory response (HVR) are considered as important factors of acclimatization to hypoxia. The objective this study was characterise ventilation pattern at different inspired oxygen fraction a model chronic anemic mice. These mice have targeted disruption 5′ untranslated region Epo gene that reduces expression such homozygous animal is severely anemic. Ventilation normoxia Epo-TAgh significantly greater than wild type, difference mainly due higher tidal volume. HVR every FIO2 suggesting chemosensitivity. Resting consumption maintained Maximal 30% lower while hemoglobin 60% compared type. This small decrease maximal probably cardiac output and/or better tissue extraction would allow these acclimatize hypoxia spite low carrying capacity. In conclusion, showed increased response. However, whether adaptations will contribute remains be determined.