Do specific virus-bacteria pairings drive clinical outcomes of pneumonia?

摘要: Bacterial pneumonia is a common contributor to severe outcomes of influenza. Epidemiological data suggest that the incidence, severity and associated bacterial pathogens differ between epidemics by geographical location within epidemics. Data from animal models demonstrate differences in both viral strains alter incidence pneumonia. For influenza viruses, evolutionary changes specific virulence factors appear ability viruses particular lineages prime host for secondary infection. Although considerably disease potential setting co-infection, underlying this finding are currently unknown. The hypothesis variation exists prevalence expressing enable efficient potentiation during should be considered as one explanation regional severity. This would have implications surveillance, vaccine development, conduct clinical trials prevention or treatment