Migration and invasion in brain neoplasms

摘要: Local invasion of the brain by neoplastic glial cells is a major obstacle to effective treatment intrinsic tumors. Invasion directly related histologic malignancy, but occurs some extent irrespective tumor grade. Because brain-to-tumor interface not well demarcated, total surgical removal rarely possible; moreover, as invading transiently arrest from cell division they are refractory radiotherapeutic intervention. Invading may also be protected action cytotoxic drugs presence an intact blood-brain barrier. The cells, having migrated several millimeters or even centimeters main focus tumor, return cycle phase under control yet unknown microenvironmental cue form recurrent adjacent original site presentation. Recent cellular and genetic information concerning factors underlying only yield suitable targets for adaptation existing therapies, lead novel approaches in glioma management.