The effects of exogenous growth factors on matrix metalloproteinase secretion by human brain tumour cells
作者： H K Rooprai , G J Rucklidge , C Panou , G J Pilkington
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摘要: Matrix metalloproteinases (MMPs) are a growing family of zinc-dependent endopeptidases that capable degrading various components the extracellular matrix. These enzymes have been implicated in variety physiological and pathological conditions including embryogenesis tumour invasion. The synthesis many MMPs is thought to be regulated by growth factors, cytokines hormones. In this study, we investigated effects five exogenous factors known expressed gliomas [epidermal factor (EGF), basic (bFGF), transforming beta (TGF-β1,2) vascular endothelial (VEGF)] on MMP-2 MMP-9 expression an ependymoma, two grade III astrocytomas, oligoastrocytoma benign meningioma. Zymogram analysis revealed depended upon cell lines used study. Growth generally up-regulated but were least effective meningioma; effect being most prominent with TGF-β1 TGF-β2 all lines. It hypothesized paracrine interplay may crucial regulation MMP glioma invasion normal brain. © 2000 Cancer Research Campaign
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idealibrary.com参考文章(32)
Morris Fishbein (), Interferon treatment of human neoplasia. Advances in Cancer Research. ,vol. 46, pp. 1- 265 ,(1986) , 10.1016/S0065-230X(08)60034-2
J. C. Reubi, S. W. Lamberts, U. Horisberger, W. Lang, R. Braakman, J. W. Koper, Coincidence of EGF receptors and somatostatin receptors in meningiomas but inverse, differentiation-dependent relationship in glial tumors. American Journal of Pathology. ,vol. 134, pp. 337- 344 ,(1989)
Masashi Tamaki, Warren McDonald, Rolando F. Del Maestro, The importance of cell density in the interpretation of growth factor effects on collagenase IV activity release and extracellular matrix production from C6 astrocytoma cells. Journal of Neuro-oncology. ,vol. 39, pp. 205- 216 ,(1998) , 10.1023/A:1005997919704
Lance A. Liotta, Tumor Invasion and Metastases—Role of the Extracellular Matrix: Rhoads Memorial Award Lecture Cancer Research. ,vol. 46, pp. 1- 7 ,(1986)
Lucien Jules Rubinstein, Dorothy S. Russell, Pathology of tumours of the nervous system ,(1977)
T. Salo, J.G. Lyons, F. Rahemtulla, H. Birkedal-Hansen, H. Larjava, Transforming growth factor-beta 1 up-regulates type IV collagenase expression in cultured human keratinocytes. Journal of Biological Chemistry. ,vol. 266, pp. 11436- 11441 ,(1991) , 10.1016/S0021-9258(18)98977-5
W.G. Stetler-Stevenson, P.D. Brown, M. Onisto, A.T. Levy, L.A. Liotta, Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues. Journal of Biological Chemistry. ,vol. 265, pp. 13933- 13938 ,(1990) , 10.1016/S0021-9258(18)77438-3
Morten Lund-Johansen, Rolf Bjerkvig, Darell D. Bigner, Peter A. Humphrey, Sandra H. Bigner, Ole-Didrik Laerum, Effect of Epidermal Growth Factor on Glioma Cell Growth, Migration, and Invasion in Vitro Cancer Research. ,vol. 50, pp. 6039- 6044 ,(1990)
Garry J. Rucklidge, Morten Lund-Johansen, George Milne, Rolf Bjerkvig, Isolation and characterization of a metalloproteinase secreted by rat glioma cells in serum-free culture Biochemical and Biophysical Research Communications. ,vol. 172, pp. 544- 550 ,(1990) , 10.1016/0006-291X(90)90707-T
Anne M. Romanic, Joseph A. Madri, Extracellular Matrix‐Degrading Proteinases in the Nervous System Brain Pathology. ,vol. 4, pp. 145- 156 ,(1994) , 10.1111/J.1750-3639.1994.TB00825.X