Coincidence of EGF receptors and somatostatin receptors in meningiomas but inverse, differentiation-dependent relationship in glial tumors.

摘要: Somatostatin (SS) receptors as well EGF have been shown to be present in various brain tumors such meningiomas or glia-derived tumors. Using receptor autoradiography for both receptors, their localization on adjacent tumor sections was investigated and a correlation attempted. In tumors, there an inverse relationship the incidence of two individual tumors: majority cases (five eight) well-differentiated astrocytomas (I-II), SS were present, but none (zero detected. undifferentiated glioblastomas, reverse situation observed, no found (0 14) (8 14). III types normally seen. These data suggest that are markers opposed receptors. meningiomas, all (27 27) large percentage (23 same However, some coincidence cell can excluded. Furthermore, effect analog SMS 201-995 basal EGF-stimulated growth culture could Nevertheless, coexistence may suggestive potential functional interaction between SS.