Comparing monoclonal antibodies and small peptidic hormones for local targeting of malignant gliomas

摘要: Monoclonal antibodies, F(ab’)2 fragments and peptidic vectors have been clinically tested for systemic locoregional treatment of malignant gliomas. Since these brain-intrinsic neoplasms are characterized by relentless tumor cell infiltration normal brain parenchyma, targeting agents require diffusive properties in order to reach invading clusters that migrate along vascular clefts axonal pathways. Tumor uptake was significantly improved using small hormone receptors, e.g. modified octreotide, following injections as compared macromolecules which only led limited stabilization the disease. More importantly, biodistribution found be superior direct intratumoral injection drug-like radioconjugates. Rapid extensive distribution within 30 minutes observed large tumors, even crossing corpus callosum bihemispheric lesions 2-3 ml radiopharmakon injected into center non-resected tumors. Distribution far more after intracavitary surgical debulking. Increased interstitial pressure gradients much larger chaotic structure space a extremely tight architecture tissue might explain this unexpected pattern. Peptidic become useful deliver radiopharmaceuticals human invasive