Planning for Intracavitary Anti-EGFR Radionuclide Therapy of Gliomas. Literature Review and Data on EGFR Expression

摘要: Targeting with radionuclide labelled substances that bind specifically to the epidermal growth factor receptor, EGFR, is considered for intracavitary therapy of EGFR-positive glioblastoma multiforme, GBM. Relevant literature reviewed and examples EGFR expression in GBM are given. The therapeutical efforts made so far using anti-tenascin have given limited effects, probably due low radiation doses migrating glioma cells brain. Low might be penetration targeting agents or heterogeneity target structure. In this article we focus on possibilities tumour instead an extracellular matrix component. There seems a lack knowledge degree intratumoral variation GBM, although seemed rather homogeneous over large areas most (n=16) presented from our laboratory. observed homogeneity was surprising considering genomic instability generally characterises highly malignant tumours. However, overexpression is, at least primary GBMs, one steps development malignancy, lose downregulate will outgrown expanding cell population. Thus, loss not critical successful therapy. Instead, it likely properties critical, detailed studies urgent.