Hyperhomocysteinemia Due to Short-Term Folate Deprivation Is Related to Electron Microscopic Changes in the Rat Brain

摘要: We investigated the effects of folate deprivation on plasma and homocysteine its cerebral microvasculature using electron microscopy. Two levels folic acid (0 mg 4 mg/kg diet) were fed to 6-mo-old male rats for 8 wk. Dietary decreased from 353.0 +/- 29.7 nmol/L 44.2 7.2 with a concomitant increase in 6.15 0.9 micro mol/L 19.5 2.7 mol/L. Plasma was negatively correlated at wk (r = -0.876, P 0.004). Electron microscopic studies brains folate-deprived revealed cytoplasmic swelling mitochondrial degeneration endothelium, perivascular amorphous fibrosis pericytic degenerative appearance cerebrocortical microvascular wall. These morphologic changes might be helpful elucidating mechanisms underlying cerebrovascular neuropathology deficiency.