Efficient ultrasound-assisted synthesis, spectroscopic, crystallographic and biological investigations of pyrazole-appended quinolinyl chalcones

摘要: Abstract Two series of new quinolinyl chalcones containing a pyrazole group, 3a–f and 4a–r, have been synthesized by Claisen–Schmidt condensation the derivatives 2-methyl-3-acetylquinoline with either substituted 1,3-diphenyl-1H-pyrazole-4-carbaldehyde or 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde in 76–93% yield under ultrasonic method. The compounds were characterized using IR, 1H NMR ESI-MS spectroscopic methods and, for representative compounds, X-ray crystallography. An E-configuration about C ethylene bond has established via spectroscopy These show promising anti-microbial properties, 4a 3e being most potent against bacterial fungal strains, respectively methoxy showed moderate anti-oxidant activity.