Metabolite-enabled eradication of bacterial persisters by aminoglycosides
作者： Kyle R. Allison , Mark P. Brynildsen , James J. Collins
DOI: 10.1038/NATURE10069
关键词:
摘要: Bacterial persistence is a state in which a sub-population of dormant cells, or 'persisters', tolerates antibiotic treatment,,,. Bacterial persisters have been implicated in biofilms and in chronic and recurrent infections,,. Despite this clinical relevance, there are currently no viable means for eradicating persisters. Here we show that specific metabolic stimuli enable the killing of both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) persisters with aminoglycosides. This potentiation is aminoglycoside-specific, it …
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