Significance of EZH2 expression in canine mammary tumors.
作者： Hyun-Ji Choi , Sungwoong Jang , Jae-Eun Ryu , Hyo-Ju Lee , Han-Byul Lee
DOI: 10.1186/S12917-016-0789-2
关键词:
摘要: Background Current studies report that aberrations in epigenetic regulators or chromatin modifications are related to tumor development and maintenance. EZH2 (Enhancer of zeste homolog 2) is one the catalytic subunits Polycomb repressive complex 2, a crucial regulator. has master regulatory function such processes as cell proliferation, stem differentiation, early embryogenesis. In humans, linked oncogenic several carcinomas, including breast cancer, dysregulation been particularly associated with loss differentiation poorly differentiated cancer. our present study, we were interested determining whether increased canine mammary tumors, which show similarities human
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