Association of spirochetal infection with Morgellons disease

摘要: Morgellons disease (MD) is an emerging multisystem illness characterized by skin lesions with unusual filaments embedded in or projecting from epithelial tissue. Filament formation results abnormal keratin and collagen expression epithelial-based keratinocytes fibroblasts. Recent research comparing MD to bovine digital dermatitis, animal infectious similar features, provided clues that spirochetal infection could play important role the human as it does illness. Based on histological staining, immunofluorescent electron microscopic imaging polymerase chain reaction, we report detection of Borrelia spirochetes dermatological tissue of  four randomly-selected patients. The association provides evidence this may be a significant factor refutes claims are self-inflicted people suffering disorder delusional. Molecular characterization found patients warranted.