Rnai molecule for thymidylate synthase and use thereof

作者: cheng long Huang , Hiromi Wada

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摘要: Disclosed is a novel RNAi molecule which can enhance the anti-tumor effect of 5-FU-type agent significantly. Specifically disclosed are: an comprising nucleotide sequence depicted in SEQ ID NO:2; and agent.

参考文章(9)
Keiichi Takeishi, Sumiko Kaneda, Dai Ayusawa, Kimiko Shimizu, Osamu Gotoh, Takeshi Seno, Nucleotide sequence of a functional cDNA for human thymidylate synthase Nucleic Acids Research. ,vol. 13, pp. 2035- 2043 ,(1985) , 10.1093/NAR/13.6.2035
Devin Leake, William Marshall, Anastasia Khvorova, Angela Reynolds, Stephen Scaringe, Functional and hyperfunctional siRNA ,(2003)
Peter J Ferguson, Olga Collins, Nicholas M Dean, Janice DeMoor, Chen Sha-Li, Mark D Vincent, James Koropatnick, Antisense down-regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5-FUdR, 5-FU and Tomudex in HeLa cells. British Journal of Pharmacology. ,vol. 127, pp. 1777- 1786 ,(1999) , 10.1038/SJ.BJP.0702728
Cheng-long Huang, Dage Liu, Jun Nakano, Hiroyasu Yokomise, Masaki Ueno, Kyuichi Kadota, Hiromi Wada, E2F1 Overexpression Correlates with Thymidylate Synthase and Survivin Gene Expressions and Tumor Proliferation in Non–Small-Cell Lung Cancer Clinical Cancer Research. ,vol. 13, pp. 6938- 6946 ,(2007) , 10.1158/1078-0432.CCR-07-1539
Shigeki Yokomuro, 茂樹 横室, 義昭 水口, Yoshiaki Mizuguchi, Toshihiro Takizawa, Takuya Mishima, 拓也 三嶋, 俊広 瀧澤, 孝 田尻, Takashi Tajiri, Rna sequence acting as rna-interference to human thymidylate synthase ,(2004)