The 'endocytic matrix reloaded' and its impact on the plasticity of migratory strategies.

摘要: An explosive growth in knowledge, the last two decades, has conferred a new dimension to process of endocytosis. Endocytic circuitries have come into focus as pervasive system that controls virtual all aspects cell biology. A few years ago, we proposed term ‘endocytic matrix’ define cellular network signalling wiring is at core blueprint. primary role endocytic matrix delivery space-resolved and time-resolved signals an interpretable format, and, such, it profound consequences on polarized supra-cellular functions, first foremost, motility. Here, describe set recent results expand this notion illuminate how dynamically plasticity migratory strategies. We further highlight impact inter-organelle contact sites motility organelle positioning process. Finally, illustrate global perturbation circuitry influences mechanics, ultimately controlling solid-to-liquid-like transition mode with potential cancer dissemination.