Serum 25-hydroxyvitamin D3 Concentrations and Carotid Artery Intima-Media Thickness Among Type 2 Diabetic Patients

作者: Giovanni Targher , Lorenzo Bertolini , Roberto Padovani , Luciano Zenari , Luca Scala

DOI: 10.1111/J.1365-2265.2006.02633.X

关键词:

摘要: Summary Objective  To estimate the prevalence of hypovitaminosis D among type 2 diabetic adults and to assess relationship between intimal medial thickening (IMT) common carotid artery, a marker preclinical atherosclerosis. Design, patients measurements  We compared winter serum 25-hydroxyvitamin D3 [25(OH)D] concentrations in 390 consecutive nondiabetic controls who were comparable for age sex. Common IMT was measured with ultrasonography only by single trained operator blinded subjects’ details. Results  The (i.e. 25(OH)D ≤ 37·5 nmol/l) higher (34·0 vs 16·4%, P < 0·001) than controls. Among patients, those (n = 130) had marked increase (1·10 ± 0·15 0·87 ± 0·14 mm, when their vitamin d-sufficient counterparts (n = 260). These also significantly haemoglobin A1c, fibrinogen C-reactive protein (hs-CRP) concentrations. In multivariate regression analysis, low 25(OH)D independently predicted (P < 0·001) people diabetes after adjustment classical risk factors, duration, HbA1c, calcium, renal function tests, inflammatory markers, use medications, presence metabolic syndrome (as defined Adult Treatment Panel III criteria). Conclusions  Hypovitaminosis is highly prevalent strongly associated increased IMT. Further investigation into whether may play role prevention atherosclerosis appears be warranted.

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