作者: Giovanni Targher , Lorenzo Bertolini , Roberto Padovani , Luciano Zenari , Luca Scala
DOI: 10.1111/J.1365-2265.2006.02633.X
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摘要: Summary Objective To estimate the prevalence of hypovitaminosis D among type 2 diabetic adults and to assess relationship between intimal medial thickening (IMT) common carotid artery, a marker preclinical atherosclerosis. Design, patients measurements We compared winter serum 25-hydroxyvitamin D3 [25(OH)D] concentrations in 390 consecutive nondiabetic controls who were comparable for age sex. Common IMT was measured with ultrasonography only by single trained operator blinded subjects’ details. Results The (i.e. 25(OH)D ≤ 37·5 nmol/l) higher (34·0 vs 16·4%, P < 0·001) than controls. Among patients, those (n = 130) had marked increase (1·10 ± 0·15 0·87 ± 0·14 mm, when their vitamin d-sufficient counterparts (n = 260). These also significantly haemoglobin A1c, fibrinogen C-reactive protein (hs-CRP) concentrations. In multivariate regression analysis, low 25(OH)D independently predicted (P < 0·001) people diabetes after adjustment classical risk factors, duration, HbA1c, calcium, renal function tests, inflammatory markers, use medications, presence metabolic syndrome (as defined Adult Treatment Panel III criteria). Conclusions Hypovitaminosis is highly prevalent strongly associated increased IMT. Further investigation into whether may play role prevention atherosclerosis appears be warranted.