A CRE1- regulated cluster is responsible for light dependent production of dihydrotrichotetronin in Trichoderma reesei.

摘要: Changing light conditions, caused by the rotation of earth resulting in day and night or growth on surface within a substrate, result considerably altered physiological processes fungi. For biotechnological workhorse Trichoderma reesei, regulation glycoside hydrolase gene expression, especially cellulase expression was shown to be target dependent regulation. Analysis regulatory targets carbon catabolite repressor CRE1 under inducing conditions revealed secondary metabolite cluster differentially regulated darkness photoreceptors. We found that this is involved production trichodimerol two polyketide synthases are essential for biosynthesis dihydrotrichotetronine (syn. bislongiquinolide bisorbibutenolide). Additionally, an indirect influence peptaibol antibiotic paracelsin observed. The synthetase genes as well monooxygenase were connected at level transcription positive feedback cycle darkness, but negative light, indicating cellular sensing response mechanism products these enzymes. factor TR_102497/YPR2 residing regulates manner. interrelationship with detected. Hence connection between primary metabolism appears more widespread than previously assumed, sophisticated distribution resources either degradation substrate (feed) antagonism competitors (fight), which influenced light.