In Vitro Activity of Colistin, Fosfomycin, and Piperacillin/tazobactam Against Acinetobacter baumannii and Pseudomonas aeruginosa in Songklanagarind Hospital, Thailand

作者: V. Chayakul , T. Hortiwakul , P. Chayakul , N. Ingviya

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摘要: A total of 118 isolates Gram-negative, non-fermentative bacilli including Pseudomonas aeruginosa (60 isolates) and Acinetobacter baumanni (58 were tested for susceptibility to colistin, fosfomycin, piperacillin/tazobactam. The minimal inhibitory concentration (MIC) fosfomycin piperacillin/tazobactam was determined using the Epsilon (E)-test method. colistin by both disc diffusion E-test methods. A. baumannii, P. 61.7 percent 50 susceptible respectively; 65 100 inhibition zone against all 11-14 mm with within MIC range 0.19-2 mg/L. In conclusion, showed little resistance very active aeruginosa. data did not support stand-alone usage fosfomycin. (J Infect Dis Antimicrob Agents 2009;26:916.)

参考文章(12)
Neu Hc, Neu Nm, Chin Nx, Synergy of fosfomycin with beta-lactam antibiotics against staphylococci and aerobic gram-negative bacilli. Drugs Under Experimental and Clinical Research. ,vol. 12, pp. 943- 947 ,(1986)
Matthew E Falagas, Michael Rizos, Ioannis A Bliziotis, Kostas Rellos, Sofia K Kasiakou, Argyris Michalopoulos, Toxicity after prolonged (more than four weeks) administration of intravenous colistin. BMC Infectious Diseases. ,vol. 5, pp. 1- 8 ,(2005) , 10.1186/1471-2334-5-1
David Berlana, J. M. Llop, E. Fort, M. B. Badia, R. Jódar, Use of colistin in the treatment of multiple-drug-resistant gram-negative infections. American Journal of Health-system Pharmacy. ,vol. 62, pp. 39- 47 ,(2005) , 10.1093/AJHP/62.1.39
Jian Li, Craig R. Rayner, Roger L. Nation, Roxanne J. Owen, Denis Spelman, Kar Eng Tan, Lisa Liolios, Heteroresistance to Colistin in Multidrug-Resistant Acinetobacter baumannii Antimicrobial Agents and Chemotherapy. ,vol. 50, pp. 2946- 2950 ,(2006) , 10.1128/AAC.00103-06
Rosa Reina, Elisa Estenssoro, Gabriela Sáenz, Héctor S. Canales, Romina Gonzalvo, Gabriela Vidal, Gustavo Martins, Andrea Das Neves, Oscar Santander, Carlos Ramos, Safety and efficacy of colistin in Acinetobacter and Pseudomonas infections : a prospective cohort study Intensive Care Medicine. ,vol. 31, pp. 1058- 1065 ,(2005) , 10.1007/S00134-005-2691-4
Anna S Levin, Antonio A Barone, Juliana Penço, Marcio V Santos, Ivan S Marinho, Erico AG Arruda, Edison I Manrique, Silvia F Costa, None, Intravenous Colistin as Therapy for Nosocomial Infections Caused by Multidrug-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii Clinical Infectious Diseases. ,vol. 28, pp. 1008- 1011 ,(1999) , 10.1086/514732
R. N. Jones, T. R. Anderegg, J. M. Swenson, , Quality control guidelines for testing gram-negative control strains with polymyxin B and colistin (polymyxin E) by standardized methods Journal of Clinical Microbiology. ,vol. 43, pp. 925- 927 ,(2005) , 10.1128/JCM.43.2.925-927.2005
Mitsuhiro Okazaki, Kyoko Suzuki, Noriko Asano, Koji Araki, Naoko Shukuya, Teruo Egami, Hidemasa Uchimura, Takashi Watanabe, Yoshimi Higurashi, Koji Morita, Effectiveness of fosfomycin combined with other antimicrobial agents against multidrug-resistant Pseudomonas aeruginosa isolates using the efficacy time index assay Journal of Infection and Chemotherapy. ,vol. 8, pp. 37- 42 ,(2002) , 10.1007/S101560200004