Eco-friendly synthesis and antiproliferative evaluation of some oxygen substituted diaryl ketones
作者： Paola Arenas , Andrés Peña , David Ríos , Julio Benites , Giulio Muccioli
DOI: 10.3390/MOLECULES18089818
关键词:
摘要: A broad variety of oxygen-substituted diaryl ketones has been synthesized by solar energy-induced Friedel Crafts acylations 1,4-benzo- and 1,4-naphthoquinones with benzaldehydes. The in vitro antiproliferative properties the photoproducts were assessed on prostate (DU-145), bladder (T24) breast (MCF7) human-derived tumor cell lines compared to non-tumor mouse fibroblasts (Balb/3T3). Among tested compounds, it was found that those containing a 3,4,5-trimethoxyphenyl A-ring, such as 12 22 are more active DU-145, EC50 values 1.2 5.9 μM, respectively. By comparing their effects three cancer lines, analogue best mean selective index (2.4).
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