Replication pattern of the p53 and 21q22 loci in the premalignant and malignant stages of carcinoma of the cervix.
作者： Aliza Amiel , Tania Kolodizner , Amiram Fishman , Elena Gaber , Zvi Klein
DOI: 10.1002/(SICI)1097-0142(19981101)83:9<1966::AID-CNCR12>3.0.CO;2-E
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摘要: BACKGROUND Loss of replication synchrony during the S-phase cell cycle has been shown to be associated with aneuploidy in malignant cells. METHODS The pattern cervical cells obtained from normal patients and preinvasive invasive carcinoma cervix was evaluated. The fluorescence situ hybridization technique applied Papanicolaou smear slides using p53 21q22 loci. Asynchrony determined by presence one single set double dots same cell. RESULTS The rate asynchrony low grade squamous intraepithelial lesions not significantly different that controls. However, higher high even carcinoma. CONCLUSIONS The authors believe these results reflect impairment control homologous loci this phenomenon may correlated phenotype tumor. Cancer 1998;83:1966-1971. © 1998 American Society.
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