Dynamic coordination of innate immune signaling and Insulin signaling regulates systemic responses to localized DNA damage

摘要: Metazoans adapt to changing environmental conditions and harmful challenges by attenuating growth metabolic activities systemically. Recent studies in mice flies indicate that endocrine signaling interactions between insulin/IGF (IIS) innate immune pathways are critical for this adaptation, yet the temporal spatial hierarchy of these events remains elusive. Here, we identify characterize a program regulates systemic response Drosophila larva localized DNA damage. We provide evidence epidermal damage induces an is kept check repression IIS activity. NFκB/Relish fat body, which required recovery activity second phase This thus coordinates across tissues, ensuring homeostasis survival animal.