Strategies to genetically engineer T cells for cancer immunotherapy
作者： Timothy T. Spear , Kaoru Nagato , Michael I. Nishimura
DOI: 10.1007/S00262-016-1842-5
关键词:
摘要: Immunotherapy is one of the most promising and innovative approaches to treat cancer, viral infections, other immune-modulated diseases. Adoptive immunotherapy using gene-modified T cells an exciting rapidly evolving field. Exploiting knowledge basic cell biology immune receptor function has fostered modify function. Highly translatable clinical technologies have been developed redirect specificity by introducing designed receptors. The ability engineer manifest desired phenotypes functions now a thrilling reality. In this review, we focus on outlining different varieties genetically engineered cells, their respective advantages disadvantages as tools for immunotherapy, promise drawbacks in clinic.
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