Sex steroid hormones do not enhance the direct stimulatory effect of kisspetin-10 on the secretion of growth hormone from bovine anterior pituitary cells.
作者： Ahmed EZZAT AHMED , Hayato SAITO , Tatsuru SAWADA , Tomoyoshi YAEGASHI , Jin JIN
DOI: 10.1111/J.1740-0929.2010.00815.X
关键词:
摘要: The aims of the present study were to clarify effect kisspeptin10 (Kp10) on secretion growth hormone (GH) from bovine anterior pituitary (AP) cells, and evaluate ability sex steroid hormones enhance sensitivity somatotrophic cells Kp10. AP prepared 8-11-month-old castrated calves incubated for 12 h with estradiol (E(2), 10(-8) mol/L),progesterone (P(4), mol/L), testosterone (T, or vehicle only (control), then 2 amount GH released in medium was measured by a time-resolved fluoroimmunoassay. Kp10 (10(-6) 10(-5) mol/L) significantly stimulated regardless treatments (P < 0.05), E(2), P(4), T had no this response. GH-releasing response hormone-releasing (GHRH, greater than that 0.05). results suggest directly stimulates release do not these Furthermore, they is less potent GHRH.
sci-hub.se 参考文章(28)
Tetsuya Ohtaki, Yasushi Shintani, Susumu Honda, Hirokazu Matsumoto, Akira Hori, Kimiko Kanehashi, Yasuko Terao, Satoshi Kumano, Yoshihiro Takatsu, Yasushi Masuda, Yoshihiro Ishibashi, Takuya Watanabe, Mari Asada, Takao Yamada, Masato Suenaga, Chieko Kitada, Satoshi Usuki, Tsutomu Kurokawa, Haruo Onda, Osamu Nishimura, Masahiko Fujino, Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature. ,vol. 411, pp. 613- 617 ,(2001) , 10.1038/35079135
T. Hashizume, H. Saito, T. Sawada, T. Yaegashi, A. Ahmed Ezzat, K. Sawai, T. Yamashita, Characteristics of stimulation of gonadotropin secretion by kisspeptin-10 in female goats. Animal Reproduction Science. ,vol. 118, pp. 37- 41 ,(2010) , 10.1016/J.ANIREPROSCI.2009.05.017
JEAN-PIERRE BOURGUIGNON, Linear Growth as a Function of Age at Onset of Puberty and Sex Steroid Dosage: Therapeutic Implications* Endocrine Reviews. ,vol. 9, pp. 467- 488 ,(1988) , 10.1210/EDRV-9-4-467
Jeremy T. Smith, Matthew J. Cunningham, Emilie F. Rissman, Donald K Clifton, Robert A. Steiner, Regulation of Kiss1 gene expression in the brain of the female mouse Endocrinology. ,vol. 146, pp. 3686- 3692 ,(2005) , 10.1210/EN.2005-0488
Brian K. Whitlock, Joseph A. Daniel, Robyn R. Wilborn, Soren P. Rodning, Herris S. Maxwell, Barbara P. Steele, James L. Sartin, Interaction of Estrogen and Progesterone on Kisspeptin-10-Stimulated Luteinizing Hormone and Growth Hormone in Ovariectomized Cows Neuroendocrinology. ,vol. 88, pp. 212- 215 ,(2008) , 10.1159/000146242
H. Kadokawa, S. Suzuki, T. Hashizume, Kisspeptin-10 stimulates the secretion of growth hormone and prolactin directly from cultured bovine anterior pituitary cells. Animal Reproduction Science. ,vol. 105, pp. 404- 408 ,(2008) , 10.1016/J.ANIREPROSCI.2007.11.005
T Hashizume, A Kumahara, M Fujino, K Okada, Insulin-like growth factor I enhances gonadotropin-releasing hormone-stimulated luteinizing hormone release from bovine anterior pituitary cells. Animal Reproduction Science. ,vol. 70, pp. 13- 21 ,(2002) , 10.1016/S0378-4320(01)00190-7
Jeremy T Smith, Donald K Clifton, Robert A Steiner, Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling. Reproduction. ,vol. 131, pp. 623- 630 ,(2006) , 10.1530/REP.1.00368
E. Gutiérrez-Pascual, A. J. Martínez-Fuentes, L. Pinilla, M. Tena-Sempere, M. M. Malagón, J. P. Castaño, Direct pituitary effects of kisspeptin: activation of gonadotrophs and somatotrophs and stimulation of luteinising hormone and growth hormone secretion. Journal of Neuroendocrinology. ,vol. 19, pp. 521- 530 ,(2007) , 10.1111/J.1365-2826.2007.01558.X
Michelle L. Gottsch, Donald K. Clifton, Robert A. Steiner, From KISS1 to Kisspeptins: An Historical Perspective and Suggested Nomenclature Peptides. ,vol. 30, pp. 4- 9 ,(2009) , 10.1016/J.PEPTIDES.2008.06.016