In vitro activity and in vivo correlates of alloantigen-specific murine suppressor T cells induced by allogeneic pregnancy.

摘要: The fetus that results from allogeneic mating in an outbred population bears a variety of antigens against which the maternal immune system reacts, but type immunity is elicited by pregnancy does not mediate graft rejection. Previous studies have demonstrated presence nonspecific non-thymus derived suppressor cells lymph nodes draining uterus (DLN) and uterine decidua during first pregnancy. These appear to be small lymphoid inhibit generation cytotoxic T (CTL) paternal alloantigens. We now report after single pregnancy, C3H A strain mice develop alloantigen-specific (Thy-1.2+, Lyt-1-2+) are distributed systemically peripheral spleen. act directly on CTL because frequency precursors ability produce helper response alloantigens remains unchanged Suppressor cell activity could detected both vitro vivo, suppression vivo was associated with increased weight 5 days inoculation tumor into pseudopregnant mice. Nevertheless, subcutaneous intrauterine inocula regressed these cells. possible role contrast non-T successful reproduction allopregnancy-induced tolerance discussed.