ORIGINAL ARTICLE: Syngeneic Immune-Dependent Abortions in Mice Suggest Paternal Alloantigen-Independent Mechanisms

摘要: Problem Recurrent immune-associated miscarriages in humans are thought to result from maternal immune responses paternal alloantigens. We investigated the role of alloantigens a mouse model immune-dependent abortion. Method study Sib-crosses C57Bl/6J (haplotype b/b) mice heterozygous for targeted hypomorphic allele tbp gene (tbp(deltaN/+)) resulted selective mid-gestational abortion 88% tbp(deltaN/deltaN) fetuses. In dams lacking mature lymphocytes (rag1-/-), nearly all fetuses survived birth, indicating abortions were immune-dependent. Allogeneic pregnancies bearing established by either hybridizing lineage BALB/cJ d/d) and mating hybrid tbp(deltaN/+) sires haplotype b/b dams, or transfer zygotes tbp(deltaN/+)x matings into pseudopregnant wild-type CByD2F1/J d/d). Results Neither hemizygous allogeneic loci nor homozygous loci, including haplotype-mismatched major histocompatibility complex (MHC), increased frequencies. Conclusion suggested that mechanisms tolerance alloantigens, mismatched MHC antigens, intact these pregnancies, yet antigen-independent mutants occurred. These data indicate that, some cases immune-mediated abortions, presence can be coincidental superfluous compromising rejection response.