Atrial fibrillation in amyloidotic cardiomyopathy: prevalence, incidence, risk factors and prognostic role

摘要: AbstractBackground: Although atrial fibrillation (AF) is a known complication of amyloidotic cardiomyopathy (AC), precise pathophysiological and prognostic characterization not available. We therefore aimed to assess prevalence, incidence, risk factors significance AF in light-chain (AL), hereditary transthyretin-related (m-ATTR) non-mutant (wt-ATTR) AC.Methods: Retrospective study 262 patients with AC (123 AL, 94 m-ATTR, 45 wt-ATTR) from single center.Results: prevalence was 15% (AL 9%, m-ATTR 11%, wt-ATTR 40%). During median follow-up 1.2 years 11 developed (2.1% person-years). Age, heart failure (HF), left ventricular (LV) ejection fraction, renal involvement, size right pressure were independently associated AF. incident HF but increased mortality. All prescribed warfarin none suffered thromboembolic events.Conclusions: In the va...