Chemoenzymatic synthesis of chiral 4-(N,N-dimethylamino)pyridine derivatives
作者： Eduardo Busto , Vicente Gotor-Fernández , Vicente Gotor
DOI: 10.1016/J.TETASY.2005.09.006
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摘要: Abstract Chiral 4-( N , -dimethylamino)pyridine derivatives have been prepared through a chemoenzymatic synthesis where the enzymatic kinetic resolution of family 4-chloro-2-(1-hydroxyalkyl)pyridines is key step for formation potentially important chiral catalysts. Pseudomonas cepacia lipase (PSL) showed excellent enantioselectivity in acylation ( R )-enantiomers E > 200) using vinyl acetate as acylating agent and THF solvent, obtaining products substrates enantiomerically pure with yields.
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