Low Dose G-CSF to Augment Host Defense and Counteract Progression of Sepsis

摘要: Multiple trauma patients and undergoing major surgical operations are predisposed to life-threatening sepsis by an apparently acquired immunological deficiency, which is accompanied a high mortality rate (40 60%) [1]. Neutrophils represent the first line of defense against invading bacteria. However, impaired neutrophil function has been reported in severely injured [2] during early septic shock [3]. Surgery resulted further depression with intra-peritoneal infections [4]. In these patients, relapses were associated diminution prior any clinical evidence for infection Thus, at risk or might benefit from prophylactic augmentation restoration function. Unfortunately, until recently, there no choice counteract granulocyte dysfunctions have described posttraumatic [2]. mice, recombinant human colony-stimulating factor (rhG-CSF) improved survival well-established model [5]. G-CSF one important hemopoietic factors plays central role precursor cell proliferation differentiation into neutrophils [6]. addition stimulation maturation, enhances variety functions neutrophils, including chemotaxis [7], superoxide generation [8], bactericidal [9] phagocytic activity [9]. Moreover, may beneficial effects on feedback regulation cytokines [5, 10]. activate hand provide anti-inflammatory effect other.