Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4

摘要: Mounting evidence indicates that oncogenic Ras can modulate cell autonomous inflammatory cytokine production, although the underlying mechanism remains unclear. Here we show squamous carcinoma antigens 1 and 2 (SCCA1/2), members of Serpin family serine/cysteine protease inhibitors, are transcriptionally upregulated by via MAPK ETS transcription factor PEA3. Increased SCCA expression leads to inhibition protein turnover, unfolded response, activation NF-κB is essential for Ras-mediated production tumour growth. Analysis human colorectal pancreatic samples reveals a positive correlation between mutation, enhanced IL-6 expression. These results indicate Ras-responsive plays an important role in Ras-associated tumorigenesis.