Left-Right Dynein Motor Implicated in Selective Chromatid Segregation in Mouse Cells
作者： A. Armakolas , A. J. S. Klar
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摘要: During cell division, copies of mouse chromosome 7 are segregated selectively or randomly to daughter cells depending on the type. The mechanism for differential segregation is unknown. Because left-right dynein (LRD) gene mutations result in randomization visceral organs' laterality, we hypothesized that LRD may also function selective chromatid segregation. Indeed, upon knock-down by RNA interference methods, depletion disrupts biased messenger presence absence correlates with observed patterns. This work supports claim functions a
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