Clonal Analysis of n-ras Gene Activation in Acute Myeloid Leukemia
作者： M. Lübbert , W. Oster , F. McCormick , R. Mertelsmann , F. Herrmann
DOI: 10.1007/978-3-642-84895-7_28
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摘要: Members of the ras gene family code for 21-kDa proteins (p21) located at inner cellular membrane. Several lines evidence suggest that p21 are involved in intracellular signal transduction pathways, thus regulating growth and differentiation. Ras bind hydrolyze GTP (Gibbs et al. 1984; Sweet 1984) show sequence homology to G (Hurley which thought participate action some cytokines. The n-ras has been shown couple receptor binding hematopoietic factors inositol lipid hydrolysis fibroblasts (Wakelam 1986). Conversely, activation by sodium fluoride presence Al3+ results expression cytokines (Yamato 1989), an activated transfected into normal cells or cell can induce cytokine these (Yiagnisis Spandidos 1987; Demetri 1988; Andrejauskas Moroni 1989) change their responsiveness towards (Kelekar Cole Leof 1987). Point mutations leading occur numerous human malignancies (for a review, see Bos 1988). Activating have reported 25%–40% cases acute myelogenous leukemia (AML). (Bos 1985; Janssen Farr However, be restricted subpopulations (subclones) leukemic (Toksoz
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