Guanfacine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension.

摘要: Guanfacine, a phenylacetyl-guanidine derivative, is centrally acting alpha-adrenoceptor agonist, with mechanism of antihypertensive action similar to that clonidine. It reduces blood pressure in patients essential hypertension at least as effectively clonidine or methyldopa. Like lower doses clonidine, guanfacine can be given once daily due its relatively long elimination half-life. Although dry mouth and sedation occur frequently higher guanfacine, their incidence than other antihypertensives; addition, troublesome side effects such orthostatic hypotension sexual dysfunction also much less agents. While withdrawal syndrome may on abruptly discontinuing administration, the symptoms are generally mild, appears occurs abrupt Thus, an effective well tolerated alternative drugs. Whether final place therapy will 'second-line' drug, initial monotherapy mild moderate hypertension, remains clarified comparative studies diuretics, calcium antagonists, beta-adrenoceptor blocking