Absence of fibroblast growth factor 2 does not prevent tumor formation originating from the RPE
作者： Alessandro Foletti , Julien Ackermann , Andrea Schmidt , Edith Hummler , Friedrich Beermann
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摘要: We have analysed the importance of fibroblast growth factor 2 (FGF2) in tumor development. In a transgenic mouse model (Tyrp1-Tag) tumors form retinal pigment epithelium (RPE), invade surrounding tissues, and metastasize to lymph node spleen. To address whether RPE formation is dependent on FGF2, we generated FGF2-deficient mice. Such mice appeared healthy exhibited no impairment or Tyrp1-Tag mice, which are lacking FGF2 (FGF2-/-) developed that spleen nodes. Tumor survival rate identical littermates expressing FGF2. Cell lines were isolated from wild-type They grow culture, pigmented vascularized tumors, when injected subcutaneously into nude either FGF2-/- FGF2+/+ genetic background. Kinetics was independent presence Together, these results demonstrate not essential for thus suggesting general may be
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